Yohimbine HCL is the synthetic version of Yohimbine extract from the yohimbe tree. Yohimbine HCL safer and results proven, due to its highly controlled dosages.
Yohimbe (the tree and bark, and its subset yohimbine (the extract), are fat-burning compounds, primarily used to lose fat during short term fasting.
Yohimbine is found naturally occurring primarily as an alkaloid in the Pausinystalia yohimbe tree (sometimes referred to as Corynanthe yohimbe), and can be found in the plant known as Rauwolfia Serpentina, as well as the Rauwolfia family of plants in general.
Yohimbine, as a molecule, is sometimes also referred to as aphordine, corynine, hydroaergotocin, and quebrachine.
Yohimbine is also an aphrodisiac and can aid erectile dysfunction in men only. This does not affect women. It is also a general stimulant and energy booster.
Yohimbine works by increasing adrenaline levels in the body, as well as inhibiting a regulatory process in fat cells – mainly stubborn fat cell receptors, which normally suppresses fat burning.
The effects of yohimbine HCL are ineffective if taken with a high carbohydrate diet, which is why Y-HCL should be taken in a fasted state.
Dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. This results in a dosage of:
- 14 mg for a 150lb person
- 18 mg for a 200lb person
- 22 mg for a 250lb person
Supplementation is most effective between meals or during short term fasting.
Caution should be exercised at higher body weight, since the cardiovascular system may not be prepared to handle the stimulation from Y-HCL. When supplementing Y-HCL for the first time, always start with a half-dose and assess tolerance before proceeding.
When pairing yohimbine with other stimulatory agents, half-dose both supplements and work up to the recommended dose cautiously, as two supplements can interact negatively.
Y-HCL does not affect sleep.
Fat Mass and Obesity
Y-HCL is an antagonist (Inactivation) of the Alpha-2-Adrenergic receptors preserves fat burning effects mediated via other mechanisms, a negation of a suppressive effect that ultimately results in more lipolysis (fat burning)
Yohimbine acts upon the adrenergic receptor system of fat cells, which regulate thermogenesis. The beta-subunits of the adrenergic receptors (targets of ephedrine) can be seen as stimulatory for fat loss as they increase the activity of the enzyme Adenyl Cyclase and subsequently cAMP levels (mainly via the b1 and b2 subunits; with b3 being less active in humans). The alpha-subunits are more suppressive of fat metabolism, in which their activation reduces activity of Adenyl Cyclase and reduces cAMP levels (specifically alpha-2). Yohimbine is a selective alpha-2 adrenergic receptor antagonist (inactivator), which inhibits activation of the suppressive set of receptors and preserves Adenyl Cyclase activity and the effects mediated via the beta receptors.
Beyond that, yohimbine itself can potentially induce fat loss vicariously through the release of adrenaline; adrenaline itself is an activator of beta-adrenergic receptors.
One study has been conducted with Yohimbine in elite soccer players taking 10mg yohimbine twice a day (20mg total) for a period of 21 days noted that, after the diet was controlled for, that fat percentage was decreased from 9.3+/-1.1% to 7.1+/-2.2% (assessed via calipers), while placebo experienced a nonsignificant increase.
0.2mg/kg Yohimbine in otherwise healthy men appears to enhance the fat burning effects of endogenous noradrenaline, and appears to be more effective during periods of exercise and attenuated if given beta-blockers; another study noted this attenuation to be measured at 70%.
- Y- HCL can cause extreme anxiety in individuals predisposed to anxiety. Yohimbine may trigger manic psychosis or suicidal episodes in people with bipolar disorder
- Yohimbine can interact with a large amount of neurological medications and should not be used in conjunction with these medication without consultation with a doctor.
- Y-HCL is not for pregnant women and those who are breastfeeding.
Yohimbine and Anxiety
If you are predisposed to anxiety, then taking Y-HCL may increase your chances of anxiety attacks.
One study that measured anxiety via EEG (using the frontal midline theta pulse as biomarker) noted that participants with less anxiety at baseline that recieving 15mg yohimbine did not influence anxiety as measured by either EEG or self-report, while those with higher baseline anxiety experienced an exacerbation of anxiety on both measures; general arousal was increased in both groups.
Stress and Panic
Due to effectively increasing noradrenaline, the neural side-effects of excess noradrenaline may result if too high a dose is taken; the most common are anxiety and panic disorders, with the later affecting susceptable persons.
This increase in anxiety may be a per se effect of yohimbine in excess, as 30mg yohimbine can induce anxiety acutely in otherwise healthy persons (assessed by the Visual Analogue Scale for Anxiety), opioid dependent persons, and in persons who are susceptable to panic attacks; where yohimbine may be able to induce panic attacks.
Do not take Y-HCL more than the recommended dosage.
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